Establishment and Validation of Sensitive Liquid Chromatography–Tandem Mass Spectrometry Method for Aldosterone Quantification in Feline Serum with Reference Interval Determination

Furlanello T, Bertolini FM, Zoia A, Sanchez del Pulgar J, Masti R.

Abstract:
Aldosterone is a crucial mineralocorticoid hormone in small animals, particularly cats, as imbalances can contribute to conditions like arterial hypertension, hypokalaemia, and chronic kidney disease. This study introduces a validated liquid chromatography–tandem mass spectrometry method for precise serum aldosterone measurement in cats, with a limit of quantification of 5 pg/mL. The method established a reference interval of 5.0–78.4 pg/mL (13.8–217.2 pmol/L) for healthy cats, providing a reliable tool for diagnosing and monitoring aldosterone-related disorders in veterinary practice.

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San Marco è approvata da Fnovi come Erogatore di formazione di sviluppo continua per i propri eventi (SPC)

Come ospedale terziario, continuiamo a dare assistenza ai nostri pazienti, sia in emergenza che per le condizioni complesse e non differibili, così come continua regolarmente l’attività del Laboratorio Analisi.