Zoia A, Gerou-Ferriani M, Drigo M, Caldin M.
Case-control study of plasma mean platelet component concentration and survival analysis for dogs with immune-mediated hemolytic anemia
J Am Vet Med Assoc. 2018 Jun 1;252(11):1384-1392. doi: 10.2460/javma.252.11.1384.
Abstract
OBJECTIVE
To determine whether dogs with immune-mediated hemolytic anemia (IMHA) had a low plasma mean platelet component (MPC) concentration and whether MPC was associated with outcome.
DESIGN
Retrospective case-control study and survival analysis.
ANIMALS
95 dogs with IMHA (cases) as well as 95 healthy dogs and 95 sick dogs without IMHA (controls) matched to cases by age, reproductive status, and breed.
PROCEDURES
Plasma MPC concentration at initial examination was compared among groups. For dogs with IMHA only, sex, age, serum urea and bilirubin concentrations, Hct, platelet count, and plasma fibrinogen, D-dimer, and MPC concentrations were evaluated for associations with survival to 42 days after initial examination.
RESULTS
Plasma MPC concentration was significantly lower in dogs with IMHA than in the other 2 dog groups. In dogs with IMHA, plasma MPC concentration was the only factor significantly associated with outcome. The optimal plasma MPC concentration cutoff value for predicting nonsurvival of dogs with IMHA was 19.1 g/dL; values ≤ 19.1 g/dL were associated with nonsurvival. Likewise, the survival curve for dogs with plasma MPC concentrations ≤ 19.1 g/dL differed significantly from that for dogs with values > 19.1 g/dL. The mean estimated risk of death for dogs with IMHA decreased by 16% for every unit increase in plasma MPC concentration.
CONCLUSIONS AND CLINICAL RELEVANCE
In dogs with IMHA, platelets appeared to have been activated to a greater degree, as determined by lower plasma MPC concentrations, than in healthy dogs or sick dogs without IMHA. Plasma MPC concentration at initial examination may be useful for predicting prognosis in dogs with IMHA.
La Clinica ed il Laboratorio San Marco rientrano tra le attività di impresa di pubblica utilità, per le quali il DPCM non determina il blocco delle attività produttive, delle attività lavorative. Applichiamo con rigore tutte le misure di legge e le raccomandazioni per limitare la diffusione dell’infezione ed una serie di ulteriori misure interne, per la salvaguardia della nostra e della vostra salute. E siamo certi della vostra comprensione e collaborazione.
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Il Direttore Sanitario Dott. Marco Caldin